The Bradford & Airedale Health of Men initiative: a study of its effectiveness in engaging with men

The Health of Men (HoM) network received funding from the Big Lottery Fund in 2003 to establish a five year programme of dedicated work with men and boys. This enabled a team of practitioners to be creative and to build upon their existing skills to generate models of working with those men in the community that are usually seen as hard to reach. The research which has accompanied of the work of team has explored why men use these new services and has demonstrated the following: • Men do care about their health • Men are willing and able to engage with their health when services are tailored to their needs • Men from different culture groups and socio-economic backgrounds who are normally seen as hard to reach were accessed. • A model encompassing a dedicated team working with men is worthy of further development Much has been learnt from this project that has great relevance to the local Primary Care Trust (PCT), but has also proved a great source of information for the development of services to men on a Regional, National and International level

Optimization of grazing incidence mirrors and its application to surveying X-ray telescopes

Grazing incidence mirrors for X-ray astronomy are usually designed in the parabola-hyperbola (Wolter I) configuration. This design allows for optimal images on-axis, which however degrade rapidly with the off-axis angle. Mirror surfaces described by polynomia (with terms higher than order two), have been put forward to improve the performances over the field of view. Here we present a refined procedure aimed at optimizing wide-field grazing incidence telescopes for X-ray astronomy. We improve the angular resolution over existing (wide-field) designs by ~ 20%. We further consider the corrections for the different plate scale and focal plane curvature of the mirror shells, which sharpen by another ~ 20% the image quality. This results in a factor of ~ 2 reduction in the observing time needed to achieve the same sensitivity over existing wide-field designs and of ~ 5 over Wolter I telescopes. We demonstrate that such wide-field X-ray telescopes are highly advantageous for deep surveys of the X-ray sky.Comment: 8 pages 4 figures. Accepted for publication on A&A (macro included

Enhancing care for older people living in nursing homes in rural Australia using action learning as a catalyst for change

The implementation of action learning workshops in three nursing homes in rural Victoria, Australia has been critical in the re-visioning of how care can be enhanced for residents. The workshops were designed with the intent of improving quality of care for residents by providing health care staff with opportunities to learn together and effect cultural change. Valuing what was accomplished well in these nursing homes was the starting point. The project was funded by a Commonwealth Government Rural Education Grant and was based on ‘My Home Life’ a popular programme that promotes quality of life and delivers positive change in care homes for older people across the United Kingdom. This paper provides an account of the project including key components of the action learning workshops and subsequent evaluation of the programme conducted in Australia. The lessons learnt throughout this project have provided the impetus to continue using appreciative inquiry and action learning to involve participants in reflecting on their practice, valuing what they do well while identifying areas that require change. Working together in a safe and respectful space provides participants with opportunity to harness their own collective wisdom and as the health professionals in this project experienced, also learn valuable skills that support progressive action that makes a difference to older people’s lives

Supporting the development of shared understanding in distributed design teams

Distributed teams are an increasingly common feature of engineering design work. One key factor in the success of these teams is the development of short- and longer-term shared understanding. A lack of shared understanding has been recognized as a significant challenge, particularly in the context of globally distributed engineering activities. A major antecedent for shared understanding is question asking and feedback. Building on question-asking theory this work uses a quasi-experimental study to test the impact of questioning support on homogeneous and heterogeneous teams. The results show significant improvement in shared understanding for both team types (27% improvement for heterogeneous and 16% for homogeneous), as well as substantial differences in how this improvement is perceived. This extends theoretical insight on the development of shared understanding and contributes one of few empirical studies directly comparing homogeneous and heterogeneous teams in the engineering design context. This has implications for how distributed teams can be more effectively supported in practice, as well as how shared understanding can be facilitated in engineering design

Spatial Correlation Function of X-ray Selected AGN

We present a detailed description of the first direct measurement of the spatial correlation function of X-ray selected AGN. This result is based on an X-ray flux-limited sample of 219 AGN discovered in the contiguous 80.7 deg^2 region of the ROSAT North Ecliptic Pole (NEP) Survey. Clustering is detected at the 4 sigma level at comoving scales in the interval r = 5-60 h^-1 Mpc. Fitting the data with a power law of slope gamma=1.8, we find a correlation length of r_0 = 7.4 (+1.8, -1.9) h^-1 Mpc (Omega_M=0.3, Omega_Lambda=0.7). The median redshift of the AGN contributing to the signal is z_xi=0.22. This clustering amplitude implies that X-ray selected AGN are spatially distributed in a manner similar to that of optically selected AGN. Furthermore, the ROSAT NEP determination establishes the local behavior of AGN clustering, a regime which is poorly sampled in general. Combined with high-redshift measures from optical studies, the ROSAT NEP results argue that the AGN correlation strength essentially does not evolve with redshift, at least out to z~2.2. In the local Universe, X-ray selected AGN appear to be unbiased relative to galaxies and the inferred X-ray bias parameter is near unity, b_X~1. Hence X-ray selected AGN closely trace the underlying mass distribution. The ROSAT NEP AGN catalog, presented here, features complete optical identifications and spectroscopic redshifts. The median redshift, X-ray flux, and X-ray luminosity are z=0.41, f_X=1.1*10^-13 cgs, and L_X=9.2*10^43 h_70^-2 cgs (0.5-2.0 keV), respectively. Unobscured, type 1 AGN are the dominant constituents (90%) of this soft X-ray selected sample of AGN.Comment: 17 pages, 8 figures, accepted for publication in ApJ, a version with high-resolution figures is available at http://www.eso.org/~cmullis/papers/Mullis_et_al_2004b.ps.gz, a machine-readable version of the ROSAT NEP AGN catalog is available at http://www.eso.org/~cmullis/research/nep-catalog.htm

The TREC2001 video track: information retrieval on digital video information

The development of techniques to support content-based access to archives of digital video information has recently started to receive much attention from the research community. During 2001, the annual TREC activity, which has been benchmarking the performance of information retrieval techniques on a range of media for 10 years, included a ”track“ or activity which allowed investigation into approaches to support searching through a video library. This paper is not intended to provide a comprehensive picture of the different approaches taken by the TREC2001 video track participants but instead we give an overview of the TREC video search task and a thumbnail sketch of the approaches taken by different groups. The reason for writing this paper is to highlight the message from the TREC video track that there are now a variety of approaches available for searching and browsing through digital video archives, that these approaches do work, are scalable to larger archives and can yield useful retrieval performance for users. This has important implications in making digital libraries of video information attainable

The Spiros imaging software for the Integral SPI spectrometer

A key tool in the package of software available for the analysis of data from the SPI spectrometer of Integral is the SPIROS system developed at the University of Birmingham. Although intended primarily for the analysis of point sources and for the extraction of spectral information, SPIROS has many additional capabilities. The software is described with particular emphasis on the most widely used modes of operation and on the relationship to other imaging and data reduction techniques.Comment: To be published in Astronomy and Astrophysics (Letters) INTEGRAL special issu

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Birt–Hogg–Dubé (BHD) syndrome is an inherited cancer susceptibility disease characterized by skin and kidney tumors, as well as cystic lung disease, which results from loss-of-function mutations in the BHD gene. BHD is also inactivated in a significant fraction of patients with sporadic renal cancers and idiopathic cystic lung disease, and little is known about its mode of action. To investigate the molecular and cellular basis of BHD tumor suppressor activity, we generated mutant Bhd mice and embryonic stem cell lines. BHD-deficient cells exhibited defects in cell-intrinsic apoptosis that correlated with reduced expression of the BH3-only protein Bim, which was similarly observed in all human and murine BHD-related tumors examined. We further demonstrate that Bim deficiency in Bhd−/− cells is not a consequence of elevated mTOR or ERK activity, but results instead from reduced Bim transcription associated with a general loss of TGFβ-mediated transcription and chromatin modifications. In aggregate, this work identifies a specific tumor suppressive mechanism for BHD in regulating TGFβ-dependent transcription and apoptosis, which has implications for the development of targeted therapies

Chandra Discovery of a 300 kpc X-ray Jet in the GPS Quasar PKS1127-145

We have discovered an X-ray jet with Chandra imaging of the z=1.187 radio-loud quasar PKS1127-145. In this paper we present the Chandra X-ray data, follow-up VLA observations, and optical imaging using the HST WFPC2. The X-ray jet contains 273+/-5 net counts in 27ksec and extends ~30 arcsec, from the quasar core, corresponding to a minimum projected linear size of ~330/h_50 kpc. The evaluation of the X-ray emission processes is complicated by the observed offsets between X-ray and radio brightness peaks. We discuss the problems posed by these observations to jet models. In addition, PKS1127-145 is a Giga-Hertz Peaked Spectrum radio source, a member of the class of radio sources suspected to be young or ``frustrated'' versions of FRI radio galaxies. However the discovery of an X-ray and radio jet extending well outside the host galaxy of PKS1127-145 suggests that activity in this and other GPS sources may be long-lived and complex.Comment: 22 pages, 11 ps figures, 1 figure in a JPG file, 3 tables. AASTEX. Accepted by The Astrophysical Journa